Abstract

Background:
Preeclampsia is a serious pregnancy complication characterized by high blood pressure and organ dysfunction, primarily affecting the placenta and kidneys. Reduced placental blood flow can have severe consequences for both the mother and fetus, highlighting the need for effective treatment options. Moringa oleifera leaves,which are known for their potent antioxidant and antiinflammatory properties, have been explored as a potential intervention to mitigate oxidative stress associated with preeclampsia.

Aim:
This study aimed to determine the effect of Moringa oleifera Leaves on CRP, MDA, and albuminuria in a mouse model of preeclampsia.

Methods:
This post controlled experimental study used a preeclampsia-induced mouse model. Female Mus musculus were assigned to five groups: (C0) negative control, (C+) positive control, (T1) treatment group 1 receiving 100 mg/kg BW/day of Moringa oleifera extract, (T2) treatment group 2 receiving 200 mg/kg BW/day, and (T3) treatment group 3 receiving 400 mg/kg BW/day. The extract was administered orally via gavage for 16 consecutive days, after which the mice were sacrificed. Malondialdehyde (MDA), C-reactive protein (CRP), and albuminuria levels were measured using ELISA.

Results:
Moringa oleifera supplementation significantly reduced MDA levels, with the lowest levels observed in the T3 group (22.44 ± 1.66). The T2 group exhibited the lowest CRP levels (2.64 ± 0.17), Albumiuria lowest level was observed in the T2 group (3.42 ± 1.09)

Conclusion:
Moringa oleifera administration effectively reduced MDA, CRP, and albuminuria levels. As an antioxidant and antiinflammatory agent, Moringa oleifera helps suppress inflammation by lowering CRP levels, inhibiting lipid peroxidation to reduce MDA, and improving symtomps of preeclampsia, as evidenced by decreased albuminuria. These findings suggest that incorporating Moringa oleifera into dietary regimens may have therapeutic effects against preeclampsia-associated symptoms.

Key words: Albuminuria, CRP, MDA, Moringa oleifera, Preeclampsia