Abstract

Objective: To establish the diagnostic effectiveness of platelets parameters i.e. platelets distribution width (PDW) and mean platelet volume (MPV) in differential diagnosis of thrombocytosis (clonal thrombocytosis /reactive thrombocytosis).
Methodology: This cross-sectional study was carried out at Hematology department at Fauji Foundation Hospital, Rawalpindi, Pakistan from Feb 2012 to March 2013. A total of 148 patients were studied. Out of these, equal number had myeloproliferative disorders (MPD) and reactive thrombocytosis (RT). The complete blood picture was done on auto-analyzer Sysmex XT (2000i) and platelet count, PDW and MPV were determined.
Results: Out of 148 patients with thrombocytosis, the range of PDW was 10-20 % for clonal thrombocytosis (CT) with a mean value of 14.3±2.2% and for RT the range of PDW was 7-13% and the mean value was 9±1.3%. The mean MPV for CT was 11.7±1.6fl and for RT was 8.50±0.6fl with a range of 8.7-18.5fl for CT and 7.2-10.4fl for RT. The t test was applied on the mean of MPV and PDW of clonal and reactive thrombocytosis (p

Key words: Clonal thrombocytosis, Reactive thrombocytosis, platelets distribution width PDW, Mean platelet volume MPV.