Lipomas are the most common benign soft tissue tumors arising from mesenchymal fibroadipose tissue. Often they are observed in the upper limbs, but especially deep palmar hand placement of these tumors is rare and they rarely create symptoms by compressing the surrounding tissue. 52-year-old female patient was admitted to our clinic with palpable stiffness, pain and numbness in his left hand palm. In her history it was learned that she had had an operation because of similar complaints in the same area about 8 months ago in another center. On radiologic examination, about 3 * 4 cm mass was detected surrounding the 5. metacarpal bone in the palmar area. The mass was excised due to clinical findings of neuropathy and ulnar nerve was freed. At follow-up neuropathic symptoms did not encounter and the patient was completely recovered without any complications.
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