Splanchnic nerve blockade is employed in the treatment of abdominal pain, resistant to medical management due to various etiologies, particularly in cases involving pancreatic cancer and pancreatitis. Different techniques are utilized during the procedure, with radiofrequency ablation (RFA) and neurolysis using neurolytic agents being the two most frequently used methods. We retrospectively examined the effects of RFA and the combination of RFA with a neurolytic agent on pain scores. A total of 15 patients (10 males, 5 females) diagnosed with pancreatic cancer (11 cases), metastatic cancer (1 case), and chronic pancreatitis (3 cases) underwent splanchnic nerve block procedures. Of these, one patient received phenol, five patients underwent RFA, and nine patients were treated with a combination of RFA and phenol. The pre-procedural pain score was 8.93±1.22, while the one-month post-procedure pain score was 4.47±2.06 (p=.001). There was no statistically significant difference in pain score reduction among the different procedures (p>.05). Splanchnic nerve block techniques yielded a significant reduction in pain scores across various diagnoses. However, uncertainties persist regarding the preferred treatment methods. Notably, the addition of phenol to RFA treatment did not result in a difference in pain score reduction when compared to RFA alone.
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