Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder characterized by thrombotic microangiopathy caused by reduced activity of the Von Willebrand factor-cleaving protease ADAMTS13. A rare case of TTP associated with cerebral venus sinus thrombosis has been reported. A 36-year-old male, who has diabetes and had recent left middle cerebral artery (MCA) infarction, presented to the emergency room with recurrent generalize tonic clonic seizer. Investigations revealed evidence of thrombocytopenia, microangiopathic hemolytic anemia and acute kidney injury. MRV brain showed cerebral venus sinus thrombosis. The association of TTP with cerebral venus sinus thrombosis is extremely rare and worth further studies.
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