Abstract

Objective
Pan-immune inflammation value (PIV),inflammation burden index (IBI) and atherogenic index of plasma (AIP), neutrophil/ high-density lipoprotein (HDL) raito (NHR), lymphocyte/HDL ratio (LHR), monocyte/HDL ratio (MHR) and platelet/HDL ratio (PHR) have been recently investigated as novel inflammatory and cardiovascular markers. The aim of our study was to compare these indices with the manic episode and remission period of bipolar disorder (BD) patients with controls and to investigate the relationship between these indices and the clinical characteristics of the patients and whether these indices can be biomarkers for the disease and manic episode.
Methods
In this retrospective observational study, data were collected from 66 patients in remission, 67 patients in manic episode and 70 controls. Differences in PIV, IBI, AIP, NHR, MHR, LHR and PHR were analyzed, logistic regression analysis was performed to identify predictors of manic episodes, and the diagnostic potential of these parameters was evaluated using ROC curves.
Results
Significant differences were found between the three groups in NHR (p

Key words: pan-immune-inflammation value; inflammatory burden index; atherogenic index of plasma; bipolar disorder; biomarker