Abstract

Background: Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of beta cells in the pancreas. Objective: This study’s goals were to look at how much CD56 was expressed in the spleen tissue of rats with type 1 diabetes and compare it to rats that were not diabetic. Methods: The method used in this study was to give rats type 1 diabetes by giving them Alloxan (120 mg/kg). The rats had diabetes for one month. As soon as the experiment was over, all the animals were put down and prepared for normal biochemical, histology, and immunohistochemical tests. Results: The study results revealed that the biochemical findings including glucose, cholesterol, and triglycerides in diabetic group were more significantly higher than that in the control group. The spleen tissue of diabetic rats was more inflamed than that of the control group, as shown by histological results. CD56 expression was much lower in the rats of diabetic group compared to the rats in the control group. Conclusion: When looked at as a whole, CD56’s role in diabetes seems to have been lost. This explains why people with type 1 diabetes have inflammatory problems.

Key words: Type 1 diabetes, CD56, histology, immunohistochemistry, expression.