Background: Presence of diabetes changes ones life image and creates demand for treatment. Long-term vascular complications are a major cause of morbidity and mortality in patients with diabetes mellitus. Patients with type 2 diabetes often show an unusual biochemical profile. There is a must need for constant screening for this life threatening complications by regular testing of biochemical and other parameters. The core issue is achieving long term glycemic control with objective to reduce fear of debilitating complications.
Objective: To assess long term glycemic control (past 3 months) by HbA1c in type 2 diabetes mellitus patients in an urban community setting. To study correlation and linear regression between biochemical tests (FBS, PPBS, lipid profile etc.) and other parameters (ECG, fundoscopy) with glycosylated hemoglobin.
Material and Methods: It is a community based cross sectional study. 183 study subjects selected from urban community who were already diagnosed of type II diabetes mellitus with active treatment for more than 6 months. Questionnaire administered with biochemical parameters CBC, urine R and M, FBS, PPBS, last reported fasting and postprandial blood sugar, lipid profile, BUN, S. creatinine and ECG, fundoscopy (R/O retinopathy). Glycosylated hemoglobin was done by standardized HPLC technique.
Result: Out of 183 study subjects, 140 (i.e. 76.5%) subjects have fair glycaemic control and 40 (23.5%) have poor glycaemic control. 33 subjects (55%) have frequency of testing for blood sugar more than 6 months had poor glycemic control and 113 subjects (91.9%) have good glycemic control with within 6 months testing for blood sugar. Out of 183 subjects, 40 (33.1%) with poor glycemic control had last reported fasting sugar more than 110 mg% and 43 (31.6%) subjects had poor glycemic control with last reported post prandial glycemic control more than 140 mg%.
Conclusion: The study shows that there is strong association between some biochemical parameters and poor glycemic control.
Key words: Type II diabetes mellitus, biochemical parameters, HbA1c
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