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Original Research

RMJ. 2025; 50(1): 125-127


Pathological Insights to Polycystic Ovary Syndrome: Crosslinking Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels with a multi-system disorder

Aafia Afridi, Muhammad Ayub Khan, Sarfaraz Khan, Haseeb Khaliq, Tasneem Azhar, Ehsan Khan.




Abstract

Objective: To investigate Polycystic ovary syndrome (PCOS) associated pathologies in term of decreased BDNF levels.
Methodology: Serum BDNF levels were quantified using Enzyme Linked Immunosorbent Assay (ELISA) from collected serum and follicular fluid samples from 100 PCOS patients and 60 healthy women as control.
Result: BDNF both in the serum (08 ng/ml) and in the follicular fluid (10ng/ml) of PCOS patients was lower in comparison to the control group (serum 25ng/ml, Follicular 17ng/ml) with statistical significance (p

Key words: BDNF, Polycystic Ovary Syndrome, metabolic disorder, multi-system disorder.






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