The prevalence of peripheral nerve injuries (PNIs) is considerably high in society, yet the outcomes of repairs remain unsatisfactory. According to reports, more than 300,000 individuals in Europe sustain these injuries each year, while over 200,000 surgeries to repair peripheral nerves are performed each year in the USA. The nervous system controls sensations and movements through a complicated mechanism that includes the peripheral nervous system (PNS) and the central nervous system (CNS). The CNS comprises the spinal cord and brain, which is the origin of twelve cranial nerves. The spinal cord, the other major component of the CNS, is comprised of three regions: the posterior, anterior, and lateral regions. The spinal nerves emerge between the vertebrae, with nerves named according to the segment from which they arise, with the PNS consisting of the spinal and cranial nerves. This review aimed to investigate the effectiveness of fibrin glue as a less complicated alternative to sutures for repairs of peripheral nerve damage, namely sciatic nerve damage. Regarding peripheral nerve courses, especially the sciatic nerve, different types of damage could occur due to trauma, musculoskeletal, autoimmune, and iatrogenic aetiologies. Different mechanisms of repair (direct sutures, grafts, nerve guidance conduits, and laser-assisted repair) were mentioned and focused on fibrin glue usage. It was found that fibrin glue is a good replacement for many repair mechanisms and could be involved in others to get a better result because it is easier for application and time-saving.
Key words: Fibrin glue, sciatic nerve, nerve graft, direct sutures, narrative review.
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