Application of next generation sequencing in forensic science [Yeni nesil dizilemenin adli bilimlerde kullanımı]
Gonul Filoglu, Irmak Sah, Muhammed Dogan, Sila Bulut Nalcaoglu, Ilksen Tavaci, Ozlem Bulbul, Tugba Unsal.
Abstract
Next Generation Sequencing (NGS) Technology has been emerged and started to use in genetic research since the 2000s. Until today, various methods which are faster, high throughput and low cost have been developed. NGS Technologies have been gradually developed and the quality of sequencing has been reached the high level and forensic genetics labs have moved to this technology for recent years. NGS Technologies provide new opportunities for forensic genetics research. NGS Technologies enable to analysis of many forensic genetic markers (as STRs, SNPs, mRNA) in only one experiment. Besides, NGS technologies are applicable for different practices which are essential in forensic researches. Among these, create of a DNA database, ancestry and phenotype studies, monozygotic twin studies, identification of body fluids and species, forensic microbiology studies can be considered. This review has been written to focus on NGS technologies in forensic genetics applications and to be a reference study for next forensic researchers.
Key words: Next generation sequencing, forensic genetics, identification
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