Vitamins and cofactors are essential micronutrients required for various biochemical and physiological processes. Insufficient intake of vitamins and mineral components or inability to digest, assimilate, or utilize them are associated with a wide range of neuromuscular diseases such as Myoclonic Epilepsy with Ragged-Red Fibres(MERRF) and Kearns-Sayre Syndrome (KSS). Well defined conditions affecting nerve and/or muscle may occur as a result of deficiencies of vitamins and/or cofactors. Considerable headway has been made in genetics that has led to the identification of causative mutations in the previously undiagnosed or clinically complex hereditary disease conditions such as "Charcot-Marie-Tooth disease (CMT), Brown-Vialetto-Laere 1 syndrome and Riboflavin-Responsive Multiple Acyl-coA Dehydrogenase Deficiency (RR-MADD)".Therefore, on the basis of antioxidant role of micronutrients in energy metabolism, it may be rational to consider use of vitamins as supplement to conventional treatments in nerve and muscle diseases. Recently, it has been shown that a subset of patients with these conditions responds to vitamin replacement therapy. This review focuses on vitamin/cofactor responsive conditions affecting nerve and/or muscle. Databases of Google Scholar, Web of Science, PubMed, and Embase were searched for relevant studies with vitamin/cofactor responsive conditions affecting nerve and/or muscle. All relevant human and animal studies were includ
Key words: Vitamins, Cofactors, Oxidative stress, Neuromuscular disease, Micronutrientsed.
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