We conducted a thorough search across four databases, yielding a total of 388 relevant publications, to assess the management of sepsis in the emergency departments (EDs) in Saudi Arabia. After reviewing 47 full-text publications, removing duplicates using Rayyan QCRI, and assessing relevance, we ultimately found four papers that met the inclusion criteria. We included four studies involving a total of 1,795 sepsis patients, and 716 (39.8%) were males. Timely administration of antibiotics is crucial in the management of sepsis. Despite the absence of significant mortality differences between the early and immediate antibiotic groups, most patients received treatment within the first hour. Especially for high-risk groups like infants, imaging and microbiological diagnosis are essential; clinical presentations often initiate empirical therapy. Delays in administering antibiotics during handovers did not significantly impact mortality and diagnostic outcomes. Early detection tools and tailored protocols, including local resistance patterns, showed promise in improving the care of sepsis patients by using structured strategies that take into account specific contextual issues. This review highlights the importance of timely antibiotics, comprehensive diagnostics, and tailored protocols
in sepsis management in Saudi Arabia’s EDs. While adherence to international guidelines is evident, local bacterial resistance patterns, diagnostic precision, and operational efficiency remain critical for optimizing outcomes. Future research should focus on larger, prospective studies with standardized metrics to enhance long-term effectiveness and improve care quality for sepsis patients in the region.
Key words: Sepsis; Emergency, Management, Saudi Arabia, Systematic review.
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