Mesenchymal Stem Cell-injected Omental Patch More Effective Promoting Wound Healing in Bowel Perforation Animal Model
Vito Mahendra Ekasaputra, Agung Putra, Adi Muradi Muhar, Jherin Varessa, Rafeni Bunga Cikita, Satya A.P. Wijaya, Mohammad Ariq Nazar.
Abstract
Introduction: Bowel perforation (BP) occurs as the complication of many gastrointestinal problems. Omental patch (OP) is one of the methods to place omentum flaps in the perforated area. Mesenchymal stem cells (MSCs) may increase regeneration process in all tissues.
Aim: to demonstrate the role of MSC in accelerating of wound healing process by analyzing fibroblast and collagen appereance in perforated bowel conditions. Methods: Using a BP rabbit model, 18 rabbit were randomly assigned into three groups: combination of umbilical cord (UC)-MSCs injection and OP (T1), OP only (T2) and vehicle control (Veh). Hematoxylin-eosin staining and Massons trichrome staining were performed to analyze the level of fibroblast and collagen. Wound length were measured using standarized caliper. Results: The study showed a significant (P
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