Aim: Individuals with depression have cognitive deficits, including diminished thinking and concentration ability, as well as memory difficulties. Certain antidepressants used for depression are recognised to positively influence cognitive functions, including learning and memory. We aimed to examine the impact of sertraline, a selective serotonin reuptake inhibitor (SSRI), on learning and memory metrics as well as hippocampus cell proliferation in depressed rats caused by a chronic mild stress (CMS) model.
Materials and Methods: 48 rats were allocated into four groups:C, CMS, CMS+S and S. CMS groups were subjected to various stressors for a duration of 15 days.On day 15, an open field test (OFT) and a forced swim test (FST) were conducted.S was delivered at a dosage of 10 mg/kg/day for a duration of 15 days using an osmotic minipump. The OFT, Elevated Plus Maze (EPM), Forced Swim Test (FST), and Novel Object Recognition Test (NORT) were conducted to assess the efficacy of S. Animals were beheaded, and hippocampal tissues were excised. Quantitative RT-PCR was employed to assess the expression levels of peptide genes (BDNF, NeuN, MASH1).One-Way ANOVA was employed for statistical analysis.
Results: In the CMS group, there was a significant decrease in OFT velocity and movement percentage compared to the control group (p
Key words: Keywords · BDNF, Hippocampus, Nestin, NeuN, novel object recognition test
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