Abstract

This study was planned to throw light on the adverse effect of natural sweetener (sucrose) and artificial sweetener (aspartame) and the possible way of alpha lipoic acid to ameliorate the deleterious effects which may produce from these sweeteners in rats. There is a significant increase of alkaline phosphatase activity of sucrose treated group in comparison to untreated one at 45and 90- day of the experiment at (P < 0.01). Administration of lipoic acid did not reduce the potential effect of sucrose. On the other hand, aspartame had no effect on the level of alkaline phosphatase either at 45-day or at 90-day of the experiment. Sucrose had no effect on the level of total serum protein at 45-day and 90-day of the experiment. Administration of lipoic acid in combination of aspartame was significantly increase the level of serum total protein at 45 day of the experiment and had no effect at 90 day of the experiment. Sucrose was significantly decreased the level of albumin /globulin at 45 days of the experiment Administration of sucrose or aspartame was significantly increased level of urea only at 90-dayof the experiment in comparison to untreated group. Lipoic acid in combination of sucrose or aspartame was significantly decreased level of urea at 90-day of the experiment in comparison to sucrose or aspartame treated group. Administration of sucrose or aspartame was significantly increased level of serum creatinine at 90-day of the experiment in comparison to untreated group. Administration of aspartame was significantly decreased and increased the level of serum uric acid at 45 and 90 days respectively while sucrose decreased uric only at 45 day of the experiment in comparison to untreated group. Administration of sucrose or aspartame was significantly increased level of cholesterol and triglycerides during the experiment in comparison to untreated group. Administration of lipoic acid in combination of sucrose or aspartame was significantly decreased level of cholesterol during the experiment in comparison to sucrose or aspartame treated group. Sucrose was significantly increased level of glucose during the experiment in comparison to untreated group. Lipoic acid in combination of sucrose was significantly decreased level of glucose during the experiment in comparison to sucrose treated group. Lipoic acid in combination of aspartame was significantly decreased level of glucose at 45-day of the experiment but had no effect at 90-day of the experiment in comparison to aspartame treated group.

Key words: aspartame, sucrose , lipoic acid