Abstract

Aim: This study aims to evaluate the effect of antibiotic therapy based on wound culture results on wound healing in patients with stage C6 -Chronic Venous Insufficiency (CVI) who have resistant stasis ulcers that do not respond to standard CVI treatments.
Material and Methods: The study included 40 patients diagnosed with stage C6 -CVI at our clinic between 2020 and 2024. All stasis ulcers were located in the medial malleolus region. Swab cultures were obtained from all stasis ulcers, and antibiograms were performed on the cultures. Based on the antibiogram results, antibiotics to which the microorganisms were sensitive were administered concurrently with standard CVI treatment. Follow-up visits were scheduled at 30 and 45 days after treatment. Demographic data, history of Deep Vein Thrombosis (DVT), pre-treatment ulcer size, and wound healing times at follow-up were recorded.
Results: The most frequently isolated microorganisms from the stasis ulcer cultures were Staphylococcus aureus (70%), Pseudomonas aeruginosa (20%), Escherichia coli (7.5%), and Klebsiella oxytoca (2.5%). The average wound healing time for patients who received antibiotics based on the culture antibiogram and standard CVI treatment was 34.5 days. In patients with stage C6-CVI, administering antibiotics according to culture and antibiogram results may shorten the wound healing time in stasis ulcers.
Conclusion: In patients with stage C6-CVI, administering antibiotics according to culture and antibiogram results may shorten the wound healing time in stasis ulcers.

Key words: Venous ulcers, wound healing, antibiotic therapy