Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation
Rissa Ismawati, chodijah Chodijah, titiek Sumarawati, agung Putra, prasetyowati Subchan.
Abstract
Background: UVB exposure can induce melanin synthesis by increasing MDA levels and suppressing interleukin-10 (IL-10) expression. Metabolite compounds in Stink bean extract may inhibit oxidative stress caused by UVB exposure. This study aimed to determine the effect of Stink bean extract gel on MDA and IL-10 levels in rat skin tissue exposed to high-intensity UVB.Methods: This study used a posttest-only control group design with a completely randomized method. The sample consisted of 24 rats exposed to 302 nm UVB radiation at 390 mJ/cm2/day, 3 times a week for 2 weeks. The study included four groups: healthy control (K1), negative control (K2), treatment 1 (K3) with 10% Stink bean extract gel, and treatment 2 (K4) with 20% Stink bean extract gel. MDA and IL-10 levels were analyzed using ELISA assay. Results: ELISA analysis showed a significant decrease in mean MDA levels in K4 (0.61±0.15) and K3 (0.71±0.11) compared to the negative control (1.65±0.30) with p
The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
We use cookies and other tracking technologies to work properly, to analyze our website traffic, and to understand where our visitors are coming from. More InfoGot It!
