This study was demonstrated that MFA-NIC cocrystal formation can be achieved by co-milling of MFA form or MFA form II and has the same diffractogram pattern. There was no amorphous phase intermediate during milling process and the cocrystal formation mechanism was predicted via intermediate eutectic mixtures. The rate of cocrystal formation was faster in MFA form II than MFA form I. The significant variations unit cell dimensions of MFA form I and MFA form II and also the polymorphic transformation of MFA form I were predicted to be influenced to the rate of cocrystal formation.
Key words: Cocrystal formation, mefenamic acid, nicotinamide, co-milling, polymorph
|
