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Efficacy of 1% terbinafine and 1% luliconazole in the management of tinea corporis and tinea cruris

Aditya Jillella, Sameer Uz Zaman, Venkateshwarlu Yeldandi, Naga Teja Pavani A.


Abstract

Background: Tinea or dermatophytosis is a fungal infection that commonly affects stratum corneum of the skin and its other appendages. Topical antifungal agents are the first-line treatment choice for dermatophytosis among them terbinafine, luliconazole, amorolfine, and sertaconazole are more effective.

Aim and Objective: The aim of the study was to assess the efficacy and safety of topical luliconazole with topical terbinafine in tinea corporis and tinea cruris management.

Materials and Methods: Study conducted on 180 cases diagnosed clinically and confirmed mycologically with tinea cruris and tinea corpis between age group of 21 and 60 years were recruited. Study consists of two groups, that is, Group 1 administered with 1% terbinafine and Group 2 with 1% luliconazole. Clinical signs such as pruritus, erythema, scaling and mycological culture, and KOH mount were assessed at the beginning, end of 1st, 2nd, and 4th weeks.

Results: The comparison of mean pruritus score at the beginning, at the end of 1st week and 2nd week was statistically significant (P < 0.05). The mean erythema score was statistically significant between two study groups from the beginning to the 4th week. The reduction of mean scaling score was statistically significant at the end of 1st week. The KOH values between two study groups showed significant difference at the end of the 1st week (P = 0.028).

Conclusion: The status of clinical signs, mycological culture, and KOH values was better in Group 1 than Group 2. Hence, 1% luliconazole is more efficacious than 1% terbinafine in the management of tinea corporis and tinea cruris for 2 weeks.

Key words: 1% Luliconazole; 1% Terbinafine; Tinea Cruris; Tinea Corporis; Erythema; Pruritus






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