Adverse drug reactions (ADRs) pose a significant challenge to patient safety, requiring a proactive culture of reporting to enhance pharmacovigilance. Despite the crucial role of ADR surveillance, barriers such as ignorance, fear of legal repercussions, and lack of communication hinder its implementation. Establishing a robust ADR reporting system demands comprehensive education for healthcare professionals and the public, leveraging technology for ease of reporting, and fostering a supportive, reflective environment. Encouraging feedback, recognition, and continuous research will strengthen ADR detection and improve global drug safety. Building this culture ensures a proactive approach to "First, Do No Harm" in patient care.
Key words: Pharmacovigilance, Patient safety, Adverse drug reactions
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