Aim: To evaluate tissue acetylcholinesterase enzyme (AChE) and oxidative stress response induced by lead acetate (PbA) and the ameliorative effect of aqueous extract of Adansonia digitata fruit pulp (AEADFP) in Clarias gariepinus. Methods: A total of 120 Clarias gariepinus (185 ± 5 g) were assigned randomly into 6 groups, namely A, B, C, D, E and F of n=20. Group A was administered borehole water for 35 days; Group B, C, D, E and F were administered PbA for 14 days and subsequently borehole water, 195 mg/L, 390 mg/L, 585 mg/L of AEADFP and 15 mg/L of di-mercaptosuccinic acid (DMSA), respectively, for 21 days. Four fish per group were randomly selected for brain and hepatic tissue samples collection for analysis of AChE activity and oxidative stress parameters respectively.Results: There was significant (p
Key words: Adansonia digitata, Clarias gariepinus, Acetylcholinesterase, Lead acetate, oxidative stress
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