This study aims to determine if mean platelet volume (MPV) can predict maternal and fetal outcomes in pregnant women during their third trimester. A retrospective case-control study was conducted at Medipol Hospital's Obstetrics and Gynecology Clinic, involving 200 women with gestational diabetes mellitus (GDM) and 200 healthy pregnant women. Data collected included age, gestational age, body mass index (BMI), and complete blood count parameters such as hemoglobin, hematocrit, thrombocyte count, and MPV values. The results indicated that the GDM group had significantly higher age, BMI, cesarean rates, and MPV values compared to the healthy group. Maternal complications like preeclampsia, preterm labor, shoulder dystocia, and fetal growth restriction were more frequent in the GDM group. Neonatal complications, including hyperbilirubinemia, hypoglycemia, transient tachypnea of the newborn (TTN), and increased admissions to the neonatal intensive care unit, were also significantly higher. A notable finding was the significant association between elevated maternal MPV values and the occurrence of TTN in newborns (p=0.043). Mothers of infants with TTN had higher third-trimester MPV values. Receiver operating characteristic (ROC) curve analysis established a cut-off MPV value of >11.35 ft for predicting TTN. The study concludes that elevated MPV in women with GDM is strongly associated with an increased risk of TTN in their newborns. MPV, being a simple and cost-effective parameter obtained from routine blood counts, could serve as a predictive marker for TTN. However, due to limitations such as the retrospective design and single-center data, further multi-center cohort studies are recommended to validate these findings and establish MPV as a reliable predictor for adverse neonatal outcomes in GDM pregnancies.
Key words: Preterm labor, mean platelet volume, platelet count, preeclampsia, diabetes mellitus, gestational
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