Introduction: The role of inflammation and immune system pathologies in individuals with Adolescent Idiopathic Scoliosis (AIS) has recently been the focus of research. It has been reported that neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR) and monocyte/lymphocyte (MLR) ratios may be markers of inflammation severity. In addition, systemic immune inflammation index (SII), including peripheral neutrophils, lymphocytes, monocytes and platelets, systemic inflammatory response index (SIRI) and systemic inflammation total index (AISI) are also known as inflammation marker indexes. This study aimed to investigate the relationship between NLR, PLR, MLR, SII, SIRI, AISI and Cobb angle in individuals with AIS.
Materials and Methods: Pediatric patients aged 10-18 years who were requested to have scoliosis radiography with a preliminary diagnosis of AIS were retrospectively screened. Cobb angles, neutrophil, lymphocyte, platelet, monocyte, neutrophil percentage, white blood cell (WBC), hemoglobin values were recorded. NLR, PLR, MLR, SII, SIRI, AISI values were calculated. Patients were divided into 4 groups according to their Cobb angles. It was examined whether there was a difference between the groups in terms of neutrophil, lymphocyte, platelet, monocyte, neutrophil percentage, WBC, Hemoglobin, NLR, PLR, MLR, SII, SIRI, AISI values. It was examined whether there was a correlation between the Cobb angle and NLR, PLR, MLR, SII, SIRI, AISI in patients diagnosed with scoliosis and having a Cobb angle greater than 10 degrees.
Results: A significant difference was observed between Groups 2 and 4 in NLR. While a positive correlation was observed between Groups 2, 3, and 4 patients with a Cobb angle greater than 0 and NLR; no correlation was observed between PLR, MLR, SII, SIRI, AISI.
Conclusion: NLR, which is known to be associated with the severity of inflammation, is a marker that correlates with the scoliosis angle in patients with AIS. Larger-scale studies are needed to elucidate the relationship between AIS and NLR.
Key words: Adolescent Idiopathic Scoliosis, Cobb angle, neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), systemic immune inflammation index (SII), systemic inflammatory response index (SIRI), systemic inflammation total index (AISI)
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