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Review Article



Helicobacter pylori associated gallbladder diseases and their progression to gallbladder cancer: A review

Naseem Fatima, Syed Tasleem Raza, Vijay Kumar, Saliha Rizvi.




Abstract

Helicobacter pylori (H. pylori), is a bacterium with spiral shaped gram-negative characteristics, affects approximately 60% of the people in India. H. pylori infection is considered as one of the causes of gastric inflammation, which results in several gastric disorders such as occurrence of ulcers in esophagus, stomach, small intestine, which may further leads gastric cancer. In addition infection with H. pylori has also shows a positive association with gallbladder diseases including cholelithiasis, cholecystitis, gallbladder polyps, and gallbladder cancer. However, due to a lack of literature, the interconnection between H. pylori and gallbladder pathologies remains unknown. In this review, it was aim to provide an up-to-date summary of the link between the environment created by H. pylori and development of gallbladder diseases. It was concluded that infection with H. pylori was linked to cholelithiasis, chronic cholecystitis, and gallbladder cancer. But available literature reports showed contradictory results. Therefore, panel of in-depth studies are needed to establish the link between H. pylori associated gallbladder diseases.

Key words: Helicobacter Pylori, Cholecystitis, Cholelithiasis, Carcinoma, Gallbladder






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