Background:
Continuous exposure to carbon black could affect the reproductive health of female animals, especially in the process of folliculogenesis. Curcumin nanoparticles are expected to maintain reproductive organ fertility through exposure to pollution containing carbon.
Aim:
The purpose of this research is to investigate the effect of curcumin nanoparticles on the number of preantral and antral ovarian follicles in white rats (Rattus norvegicus) exposed to carbon black.
Methods:
This study used 30 female rats divided into five groups. The negative (K-) and positive (K+) control groups were given aquades + Na-CMC 0.5% orally, while the treatment group received different doses of curcumin nanoparticles, namely in the P1 (50 mg/kgBB), P2 (100 mg/kgBB), and P3 (150 mg/kgBB) groups, respectively, via oral administration. After that, K+, P1, P2, and P3 were exposed to carbon black with a concentration of 1064 mg/m3 for 6 hours a day for 30 days. The ovarian organ would then be made histopathological preparations to examine the number of preantral and antral follicles with HE staining.
Results:
The results showed a significant difference (p
Key words: Affordable medicines, Antral follicular, Carbon black, Curcumin nanoparticles, Preantral follicular
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