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Original Article



Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus

Hassan Abdulsalam,Joseph John Gadzama,Mohammed Adam Chiroma,Sani Dahiru,Halima Idrisa Gambo,Jamila Abdulhamid Atata,Sohnap James Sambo,Sani Adamu.




Abstract
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Aim: To evaluate serum hepatic changes induced by lead acetate (PbA) and the ameliorative effect of aqueous extract of Adansonia digitata fruit pulp (AEADFP) in Clarias gariepinus.
Methods: A total of 120 Clarias gariepinus (185 ± 5 g) were assigned randomly into 6 groups (A, B, C, D, E and F) of n=20. Group A was administered borehole water for 35 days; Group B, C, D, E and F were administered PbA for 14 days and subsequently borehole water, 195 mg/L of AEADFP, 390 mg/L of AEADFP, 585 mg/L of AEADFP and 15 mg/L of dimercaptosuccinic acid (DMSA), respectively, for 21 days. Four fish per group were randomly selected on weekly basis for serum biochemical analysis of hepatic function markers.
Results: There was significant (p

Key words: Adansonia digitata, Clarias gariepinus, Hepatic function parameters, Lead acetate,





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