Neuro-ophthalmic interface: Investigating the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in pathology of diabetic retinopathy
Durga Devi, Moeed Ullah Khan, Naeemullah Syed, Zain ul Abden Bilal Ahmed, Abdul Munim, Ehsan Khan.
Abstract
Objective: To investigate the therapeutic potential of Glial cell-derived neurotrophic factor (GDNF) in managing diabetic retinopathy (DR) by exploring its neuroprotective effects on retinal cells and its ability to mitigate disease progression.
Methodology: This study involved 150 subjects (68 male, 82 female) including 34 healthy controls and 116 patients with DR, enrolled from OPDs and clinical care settings with mean age of 53±6.7 years. Plasma samples were subjected to Enzyme linked Immunosorbent Assay for the determination of GDNF levels. HbA1c (%) and Fasting Glucose levels (mmol/L) were used as confounders. Statistical analyses were done via SPSS 26 (T-test, significance value p
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