Abstract

Background: Sleep deprivation acts as a potential risk factor for causing metabolic imbalance in our body. It increases cortisol level and contributes to insulin resistance and dyslipidemia. Hence it is necessary to identify the importance of adequacy of sleep in optimizing lipid metabolism.

Objective: To find out the impact of sleep deprivation on the lipid profile among healthy volunteers

Methods: Participants sleep quality was assessed by administering the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The lipid profile parameters like Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL) and Very Low-Density Lipoprotein (VLDL) were obtained from their clinical records. Based on PSQI scores study population was divided into Group A (Score < 5) and Group B (Score ≥5).The statistical analysis was performed by using students paired t test. Correlations of lipid profile with their quality of sleep were performed using Pearson’s correlation.

Results: The PSQI values were also found to be increased in group B compared to group A. When compared with group A, group B showed increased TG, LDL and VLDL levels with a p value of 0.0017,0.000,0.0517 respectively.TC (0.832) and LDL (0.9144) showed positive statistical correlation with high PSQI score. HDL(-0.5542) showed negative correlation with high PSQI score. TG and VLDL showed weak positive correlation.
Conclusion: In our study the participants with high PSQI score had more sleep disturbance and abnormal lipid profile when compared to participants with normal PSQI score. So, quality of sleep plays an integral role in preventing dyslipidemia and cardiovascular disorders

Key words: Pittsburgh Sleep Quality Index (PSQI), Triglycerides(TG), High Density Lipoprotein (HDL) , Low-Density Lipoprotein( LDL)