Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study
Renu Meena Mathialagan, Deepalakshmi K.
Abstract
Background:
Gestational Diabetes Mellitus (GDM) is a most common complication occurs during pregnancy. Thyroid hormones are the critical regulators of body metabolism, influencing both maternal and fetal outcomes during pregnancy. The pregnant women with hypothyroidism are more prone to develop increased insulin resistance which potentially contributes to the development of GDM.
Objective:
To find out the association of thyroid hormone levels with blood sugar levels in GDM women
Methods:
This cross-sectional study was conducted among 60 pregnant women having Gestational Diabetes Mellitus in the second and trimester of pregnancy Based on Thyroid Stimulating Hormone values, they were divided into two groups (A & B).Fasting Blood Sugar (FBS) and the Post Prandial Blood Sugar (PPBS) were noted for both the groups. Association of thyroid profile with their blood glucose levels was performed using Pearson’s correlation. Students paired ‘t’ test was employed to analyse parametric data.
Results:
The fasting blood sugar levels were found to be increased (115.448 ± 32.361) in comparison to patients of normal TSH values with p value 0.0032. The post prandial blood sugar levels (184.379± 53.751) were also found to be increased (p -0.0084). On correlation with FBS, TSH values showed no statistical significance in both groups. The post prandial blood sugar levels showed statistically significant correlation with higher TSH value (p value 0.000273) when compared to people with normal TSH values.
Conclusion:
In our present study, we observed the significant increase in the blood glucose levels in GDM women with high TSH values.Thus early screening of GDM women for thyroid function reduce the thyroid dysfunction in fetus
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