Abstract

Gliomatosis cerebri is a rare diffuse involvement of the central nervous system by a malignant glioma that permeates the brain extensively
without destroying the neural architecture. It involves more than two of the lobes. Oligodedroglial component can be predictive for a
better prognosis. This is a report of two patients: a 33-year-old female patient and a 58-year-old male patient. A stereotactic biopsy was
performed for our first patient. She was diagnosed with grade 2 astrocytoma. The second case was a grade 3 patient who was diagnosed
with tumour infiltration in line with gliomatosis cerebri. Both cases underwent external beam radiotherapy at 44 Gy and 50 Gy, respectively,
with a helical tomotherapy device. The patients tolerated the cure quite well and no acute complications (except for grade 1 skin reactions)
were observed during the therapy. Radiotherapy volume and treatment dose are still controversial in the treatment of gliomatosis cerebri.
Partial or whole brain radiotherapy can be applied.

Key words: Gliomatosis Cerebri; Radiotherapy; Tomotherapy.