Bacteremia due to a VIM-1 Producing Klebsiella Pneumoniae Isolate from an Acute Lymphoblastic Leukemia Patient in Antalya

Ann Med Res. 2014; 21(4): 291-293

Nevgün Sepin Özen¹, Dilara Öğünç², Gözde Öngüt², Derya Seyman³, Duygu Dağlar⁴, Betil Özhak Baysan², Dilek Çolak², Volkan Hazar⁵, Thierry Naas⁶

Abstract
A Klebsiella pneumoniae clinical isolate resistant to imipenem was recovered from blood culture of a 4 years old child with the diagnosis of acute precursor B cell lymphoblastic leukemia. PCR assays of Klebsiella pneumoniae isolate were positive with blaCTX-M and blaVIM genes. Sequence analysis of the 160 bp amplicon matched with blaVIM 1. Patient was discharged on the 15th day of ciprofloxacin theraphy with remission. We report here the first VIM-1 positive Klebsiella pneumoniae isolate case from Akdeniz University Hospital. Urgent and rapid precautions must be preferred including antibiotic policy and infection control practices when the first case with different resistance patern is detected. Key Words: K. Pneumoniae; Metallo-Β-Lactamases; VIM 1.