Home|Journals|Articles by Year|Audio Abstracts
 

Original Research

Ann Med Res. 1995; 2(4): 330-335


Hepatotoxic and Nephrotoxic Effects of Acetaminophen in New-Born and Adult Rats Comperatively

Mukaddes Eşrefoğlu, M D, PhD*, Mukadder Ayşe Selimoğlu, M D**, M. Akif Çiftçioğlu, M D.PhD***,  Akçahan Gepdiremen, M D, PhD****, Mehmet Parlak, M D***** 

.




Abstract


 

This study was planned to demonstrate acetaminophen hepatotoxicity and nephrotoxicity in new-born and adult rats comperatively. Ten newborn and ten adult male Wistar albino rats were used and in each group four rats were administered 300mg/kg and four 500mg/kg acetaminophen intraperitoneally. Spontaneous death was not observed; after 8 hours the animals were killed by decapitation. Liver and kidney sections were stained with hematoxylin and eosin. In newborn rats at 300mg/kg dose small number of necrotic cells were observed and all the animals at 500mg/kg dose developed mild centrilobular hepatic necrosis, whereas in adult rats at 300mg/kg dose moderate and at 500mg/kg dose severe centrilobular hepatic necrosis was observed.

The severity of the renal injury was not different at 300mg/kg and 500mg/kg acetaminophen group in adult and new-born rats. This toxicity was not dose-dependent and age-dependent. In all groups, there was severe acute tubular necrosis.

Key words: Acetaminophen, hepatotoxicity, nephrotoxicity, rat, newborn






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.