We have compared the anxiolytic effect of midazolam and diazepam with placebo. 45 patients, ASA I or II, in three groups were studied. Pretreatment evaluation was performed on the day before surgery using measurements of subjective (Anxiety Visual Analogue Scale-AVAS) and behavioural (Hamilton Anksiety Test-HAT) variables. At the operating theatre, patients received 0.08 mg/kg i.m. midazolam, 0.15 mg/kg diazepam i.m. or placebo. Tests were repeated 45 minutes after premedication. We found that diazepam and placebo are equally effective and midazolam is more anxiolitic than diazepam and placebo.
Key Words: Premedication, Midazolam, Diazepam, Anxiety
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