Pentachlorophenol (PCP) is a general bi oci de used worldwide in a variety of industrial areas. It has bactericidal, fungicidal, insecticidal, herbicidal and molluscicidal properties. Nowadays PCP and its salt are mainly applied in wood, followed by textile and leather preservation. Because of its numerous and different applications PCP has become widely distrubuted in ecosystem. Its acute and chronic toxicity is due to interference with oxidative phosphorylation and DNA damage.
In this study, the absorbtion risk of PCP by dermal administration was investigated. The pomades which prepared at the levels 1, 3, 5, 50, 100 and 200 ppm NaPCP/axonge was treated to the Wistar Albino rats as a single dose by dermal administration during one week. The urinary excreation of PCP was detected at the 50 ppm and upper doses. At 24-36 hr, the excreation is increased the highest levels. At the 7 th of treatment, the experimental animals were autopsied and than liver, kidneys, muscle and brain tissues were analyzed. PCP residues, there were in the muscle, liver and kidneys for 5, 50 and 200 ppm or upper application doses respectively. In this study also, wearing leather samples containing 12 ppm PCP was kept in contact to the back of the rat skin which was prepared by removal of fur for a period of one week. In the urinary of rats, it is detected 96±18 ng/ml PCP at the 36-48 hr. Tissues were analyzed at the 7 th day. The residue, there was only the muscle tissue as 50±15 ng/g.
PCP has led to a substantial environment contamination is established that can be absorbed in the body by dermal from leather. Because of the potential toxic effects on the puplic health, its applications should be prohibited.
Key Words: Pentachlorophenol, rats, dermal absorption, residue, urine, tissues, leather.
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