In our study, we aimed to determine the effects of propofol administration on hepatic functions. Having approval of local ethic comitee, 20 males, 3 months old, New Zealand rabbits weighing 2500 ±750 g were assigned to two groups. While 10 rabbits were studied as the control group in the same laboratory conditions, on the other 10 rabbits following an induction dose of 10 mg/kg, anesthesia was maintained with an infusion of propofol administered at a rate of 50 mg/kg/h. The average duration of infusion was 20 minutes giving intervals of 24 hours between the infusion periods the procedure lasted for 20 days. 24 hours after the last infusion period, 10 ml samples of blood were collected to determine serum ALT, AST, alkaline phosphatase, GGT, tryglicerides, total lipid, total cholesterol, glucose, total bilirubin, plasma albumin, and total protein levels. Following hepatectomy, histopathological indices were compared. Mann-Whitney U and Chi-Square tests were used to analyse the data and p< 0.05 was considered as significant. No differences were found in all of the biochemical parameters other than serum trygliceride and total lipid levels showed a statistically significant increase as compared the control group. Also no histopathological change was observed in the propofol group. As a result we conclude that monitoring blood lipid concentrations during repeated administrations of propofol is essential in order not to lead any effect to high lipid levels. [Journal of Turgut Özal Medical Center 1998;5(1):7-10]
Key Words: Propofol, hepatic function, repeated doses
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