Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Review Article

Ann Med Res. 1994; 1(4): 342-345

The cancerogen effects of some chemicals substances of tobacco in various organs


Dr. Haydar ÖZTA*




This review summarises evidence relevant to the involvement of N-nitroso com/Htunds in the induction of tobacco-related cancers in man. ('ancers of the oral cavity, lung, oesophagus and pancreas will be discussed. Human exposure to nitrosamine com/>ounds in tobacco products is more intense and widespread than from any other known source. Many substances, such as N-nitroso com/founds. 4-(N-nitrosomethyIamino)-I-(3 pyrdyl)-1-butanone and N'-nitrosonornicotine and /xilynuclear aromatic hydrocarbons available in tobacco may involve in causing cancers of the oral cavity, lung, oesophagus and pancreas in tobacco users. NNK and its metabolites have been shown to induce tumours in experimental animals. Both NNK and benzo[a/pyrene active the K-ras oncogenes with mutations in codon 12 were delected in 13 of 45 adenocarcinomas obtained from the lungs of smokers. The reduction or elimination of these substances /rom tobacco products would pnihahly lead to a decrease in the incidence of these cancers. [Journal of Turgut Özal Aiedical Center 1(4) 342-345.1994/

Key Words: Tobacco, cancer

Full-text options

Full-text Article

Progress in Orthopedic Science


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.