Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Review Article

Ann Med Res. 1994; 1(4): 321-323


Molecular basis of HIV resistance to zidovudine and its detection by polymerase chain reaction (PCR)

 

Rıza DURMAZ, Ph.D.*

.

Abstract

 

Zidovudine (AZT) therapy decreases both mortality and the incidence of op/xirtunistic infections in the patients injected with human immunodeficiency virus (Iill'). The resistance to AZT. however, is an important problem. This resistance is associated with the point mutations at codon 41 (Met to Leu). 6~ (As/) to Asn). ~() (Lys to Arg). 215 (Thr to Phe or Tyr) and 2/9 (Lys to (llu) in the reverse transcriptase codin}’ region of HH' pot gene PCR amplification technique is used most commonly to determine these mutations. /Journal of Turgut (hal Medical Center 1(41:321-323.1994

Key Words: Zidovudine , HIV,. PCR..


Full-text options

Full-text Article




Advertisement
Journal of Complementary Medicine Research

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.