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Ann Med Res. 1996; 3(4): 306-310


The Investigation of the Responses to Phytohemagglutinin in the Patients of non-Hodgkin?s Lymphoma who were Candidates for High Dose Chemotherapy, Autologous Bone Marrow, or Peripheral Stem Cell Transplantation

İ. Halil Özerol, MD1, Mustafa Şenol, MD2, Ana Ageitos, MD1, James E. Talmadge, PhD1

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Abstract


 

Phytohemagglutinin (PHA) is principally a T lymphocyte mitogen, producing a greater stimulatory effect on CD4+ helper/inducer T lymphocytes than on CD8+ suppressor/cytotoxic T cells. In this study, we investigated if there are differences in the mitogenic response to PHA between autologous bone marrow (BM) and granulocyte-monocyte colony stimulating factor (GM-CSF)-mobilized peripheral stem cell (PSC) products as well as to normal peripheral blood leukocytes (PBL). BM and PSC products from 24 patients with non-Hodgkin's lymphoma (NHL) were collected and assays of cell proliferation in response to PHA were performed both before and following 5 days co-incubation with IL-2. The proliferative response to PHA by cells from both PSC and BM products were significantly lower than normal PBL (p






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