Abstract

 


Donor shortage and rejection are very important problems in lung transplantation. Lobar transplantation from parents may be a solution for these problems. Two lobar transplantations from a mother dog to two puppies and one lobar transplantation from annother mother to one puppy were performed in our animal laboratory. Operations were performed without cardiopulmonary bypass, and central venous pressure, invasive arterial pressure and oxygenation were monitorized. Any immune suppresive medication was not used except one dose of preoperative corticosteroid. The mother underwent left pneumonectomy, then two lobes were prepared and transplanted to the left hemithoraces of two pneumonectomized puppies as left lungs. Left lower lobectomy was performed in the other mother dog and that lobe was transplanted to her pneumonectomized puppy as left lung. The mother underwent pneumonectomy died postoperatively because of anesthetic complications and each of two puppies received pulmonary lobes lived for 9 and 17 hours postoperatively and died because of respiratory insufficiency. The second mother underwent lobectomy survived without any complication but her puppy received left lower lobe died on postoperative day six from acute alveolar damage. Pulmonary lobar transplantation is technically feasible in dogs. Living-related lobar transplantation may be a solution for donor shortage problem in pediatric age group. [Journal of Turgut Özal Medical Center 1996;3(4):284-288]

Key Words: Pulmonary, lobe, transplantation