The Beckman Synchron CX3 otoanalyzer is a reagent-dependent clinical analyzer. Because of its advantages such as easy usage, accurate and precise results and working continuously for 24 hours it is used in our laboratory for stat analysis. But the analyzer has also some important disadvantages. It has an unopened system, requires much more maintenance procedures and large reagent volum. Because of its too high reagent cost we were obligated to search an alternative reagent and have produced some reagents used on the Synchron CX3. When we compared linearity of the reagents, we observed that they had same usable lineer test ranges (serum: from 0 to 25 mg/dL ; urine: from 10 to 40 mg/dL). We searched accuracy of the results using same control serum and found correlation coefficient among them equals to 0.999. We also compared the results obtained from different serum and urine samples by linear regression, and found the relation between them as y = 0.981x - 0.02. In addition to these criteria, we determined that both of reagents were not affected from hemolysis but were affected from high degress of lipemia and bilirubinemia. ^s a result, we observed that creatinine reagent produced in our laboratory had completely same properties with original Beckman creatinine reagent, but our reagent was cheaper than original reagent at least 10 times. [Journal of Turgut Ozal Medical Center 1997;4(2):182-186]
Key Words: Synchron CX3, creatinine reagent
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