H2 blockers have been used in gastric and duodenal ulcer and non-ulcer dyspepsia for years. Nowadays these drugs are used for maintenance therapy after Helicobacter pyolori (Hp) eradication. Aim of this study was to evaluate the effcacy and differences of ranitidin and famotidin plus dual antibiotic therapy in Hp positive non-ulcer dyspepsia patients. Hp positive patients with documented non-ulcer dyspepsia were randomised into two groups. First group was given amoxicillin 1gr bid, clarithromycin 500 mg bid for one week plus ranitidin 300 mg one a day for one month and second group was given amoxicillin 1 gr bid, clarithromycine 500 mg bid for one week plus famotidin 40 mg one a day for one month. Endoscopy with a biopsy was performed at enrollement and at 6 weeks. Hp infection was cured % 83,3 of those treated with ranitidin plus dual antibiotics (RAC) and in % 82.6 of those treated with famotidin plus dual antibiotics (FAC). Sypmptoms disappeared in % 87.5 of those treated with ranitidin plus dual antibiotics and in % 86.95 of those treated with famotidin and dual antibiotics. There were not any statistically significant differences between famotidin or ranitidin plus dual antibiotics combinations in patients with Hp positive non-ulcer dyspepsia.
Key words: H2 blockers, amoxicillin, clarithromycin, Helicobacter pylori eradication.
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