Abstract

 

Inherited disorders of amino acid metobolism or homocysteine metobolism have been implicated in the pathogenesis of vascular disease. The authors investigated the clinical significance of homocysteine level determination in diagnosis of coronary artery disease (CAD). The study patients (n=80), based on angiographic results, were categorized as a normal coronary group (n=30) and a CAD group (n =50). Patients with coronary artey disease had a higher homocysteine level than control subjects (19.47 ±7.13 vs 9.21±5.14 nmol/ml, p