Aim: We aimed to investigate the myocardial effects of the addition of captopril, a sulphydryl -containing angiotensin converting enzyme (ACE) inhibitor and lisinopril, a non -sulphydryl-containing ACE inhibitor to the prime solution and cardioplegia.
Material and Methods: Isolated rat heart model was used for the study. Rats were allocated into three groups: a control group, lisinopril group and captopril group. For all groups, cardioplegic arrest was achieved following 20 minutes of perfusion and 30 minutes of ischemia with con tinuous cardioplegic infusion and 30 min of reperfusion following ischemia were performed. According to study group, lisinopril or captopril were added to the prime solution and cardioplegic solution. Coronary blood £low, cardiac oxygen consumption, CPK, L DH,
AST secretions were measured in perfusion and reperfusion periods.
Results: Both drugs, compared to the plasebo group, caused statistically significant increase in coronary blood flow during perfusion and reperfusion phases and cardiac oxygen consumpt ion at minute 30 of reperfusion. Conclusions: We concluded that, as ACE inhibitors have an increasing effect on coronary blood flow, they may be used in coronary artery disease cases with high preoperative risk, in hyperthropic myocardium with increased oxygen demand and cases with expected long CPB (cardiopulmonary bypass) durations. We obtained similar results with both drugs, therefore we assume that —SH groups don’t play a major role in these effects.
Key words: ACE inhibitors, Isolated rat heart, Coronary flow
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