Abstract

 

Objectives: To compare of the efficacy of empirical antibiotic regimens in febrile neutropenic patients in in Adult Hematology Clinic of Turgut Ozal Medical Center.

Material and methods: Four different antibiotic regimens Ceftazidime+Amikacin (n=19), Imipenem+Amikacin (n=14), Cefepime+Amikacin (n=20) and Sulbactam/Cefoperozone+Ami-kacin (n=20) were assessed as initial empirical therapy in febrile neutropenic patients.

Results: Seventy-three febrile neutropenic episodes in 43 patients were evaluated. There was no significant difference in the efficacy and toxicity of antibiotics between the four different regimens (p>0.05).

Conclusion: All of the four empirical antibiotic regimens were equally effective and well tolerated as initial therapy for neutropenic patients with fever.

Key words: Febrile neutropenia, empiric therapy.