Pulmonary thromboembolus is a disease with high mortality and morbidity. In addition to well known and
frequent risk factors, there are some rare congenital predisposing factors. In five of 43 patients (11.6%) diagnosed
as pulmonary embolus between 1998 and 2001 in our clinic we detected a genetic risk factor for venous
thromboemboli. Except one patient, there were no formerly known genetic risk factor. Due to our results, it can
be proposed that the genetical predisposition should be searched in patients who developed venous
thromboemboli without any known risk factor. We discussed 3 patients with antiphospholipid syndrome, one
patient with protein C deficiency and one patient with protein S deficiency and activated protein C resistance
(APC-R), in total 5 cases, with regard to current literature.
Keywords: Antiphospholipid Syndrome, Protein C Deficency, Protein S Deficency, Activated C Resistance,
Pulmonary Thromboemboli
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