Abstract

 

Background and Design: Tinea versicolor is a frequent superficial fungal infection caused by a lipophilic yeast;

Malessezia furfur. Topical ketoconazole shampoo and systemic itraconazole can be used for the treatment of tinea

versicolor. In this study, the efficiency of itraconazole versus itraconazole plus 2% ketoconazole shampoo in the

treatment of tinea versicolor is evaluated retrospectively.

Materials and Methods: The patients, who were admitted to dermatology department between 1998-2002 and

diagnosed as tinea versicolor, were retrospectively evaluated. The patients who had disseminated lesions and were

administered only itraconazole and itraconazole plus 2% ketoconazole shampoo were enrolled in the study. Fifty

one patients; 29 (56.9%) male, 22 (43.1%) female were examined. Thirty two (62.7%) patients were administered

itraconazole and 19 (37.3%) patients itraconazole plus 2% ketokonazole shampoo.

Results: In the itraconazole group 21 (65.6%) patients recovered, and 11 (34.4%) patients did not. In the

itraconazole plus 2% ketoconazole shampoo group the result were 17 (89.5%) and 2 (10.5%) respectively. These

results showed that there was no significant difference in efficacy between the two treatment methods.

Conclusion: In this report, it is shown that the recovery ratio in tinea versicolor lesions was higher in itraconazole

plus 2% ketoconazole shampoo group than single itraconazole group, but this result is not statistically significant,

and it is concluded that 2% ketoconazole shampoo may be combined by itraconazole in for the treatment of

generalized tinea versicolor lesions.

Key Words: Tinea Versicolor, İtraconazole, Ketoconazole Shampoo