Home|Journals|Articles by Year|Audio Abstracts
 

Original Research

Ann Med Res. 2006; 13(4): 221-226


Comparative Effects of Ovariectomy and Flutamid on Body-Uterus Weight and Uterine Histology in the Ovariectomized Rat Model+

 

Berna Güney Saruhan*, Davut Özbağ***, Nurullah Özdemir**, Yakup Gümüşalan***

.




Abstract


 

Objective: To determine the effect of flutamide on uterine histology and to ascertain whether flutamide regulates body weight gain in the ovariectomized rat model.

Materials and Methods: We used 36 sexually mature female Wistar-Albino rats in this study. The study was performed in the Department of Medical Science Application and Research Centre of Dicle University, Diyarbakir. We divided the model rats into 3 groups: group 1- control group, group 2- sham-operated group and group 3- bilaterally ovariectomized group. In addition, we gave flutamide to group 3.

Results: We found that the body weight was higher in the ovariectomized rats than the control rats, unlike the decreased uterine net weight. Furthermore, body weight decreased slightly after flutamide therapy, however uterine net weight increased. After flutamide applications, the length of uterinal epithelium, the number of uterinal glands, infiltration of the stromal cells increased and the lumen of uterinal glands were dilateded.

Conclusion: As a result, an improvement was observed after flutamide applications while bilateral ovariectomy was determined to cause atrophy in the uterine epithelium of rat. Our study may be source for further research examining the relationship between the androgen receptor antagonist flutamide and reproductive function in female rats.

Key Words: Flutamide, Anti-androgen, Ovariectomy, Uterine histology, Body weight






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.