We aimed to evaluate clinicopathologic characteristics of Malignant Mixed Müllerian Tumor of the ovary (OMMMT) that is a rare malignancy.
A total of 5 cases diagnosed with OMMMT at Aegean Obstetrics and Gynecology Training and Research Hospital, Department of Gynecologic Oncology, between 1998 and 2006, were retrospectively analyzed. Demographic and disease-related characteristics, treatment modalities and outcome were evaluated.
The median age was 54.5±8.2. A pelvic mass and ascites were the most common presentations. Three patients were diagnosed with advanced diseases (two FIGO stage IIIC and one stage IV). All patients underwent cytoreductive surgery (3 optimal, 2 suboptimal) and platinum based cytotoxic chemotherapy. One patient with stage IV disease developed recurrence 3 months after surgery. Second line chemotherapy (carboplatin + ifosphamide + mesna + etoposide) was administered in this patient. The mean follow-up was 18.6±3.5 months. At the end of the study, only one patient was alive and progression-free.
Although clinical presentation and treatment methods of ovarian MMMT are similar to those of epithelial ovarian cancer, the prognosis is generally poorer. Clearly, new systemic treatment modalities are needed to improve prognosis.
Key Words: Malignant mixed mullerian tumor of the ovary, Treatment, Prognosis
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