Abstract

Double-Hit lymphoma is an aggressive B-cell malignancy with a high proliferative rate that may be fatal within months if not treated promptly. We presented a very aggressive and fatal case of a Double-Hit Lymphoma. 18 years old male patient referred Ear-Nose-Throat outpatient clinic due to swelling under the chin and an excisional biopsy was performed. High grade Burkitt like lymphoma CD20 (+) was reported. Approximately 12 months after diagnosis patient who was accepted as a stage IIIB according to Ann-Arbor staging system died of disease progression despite the various treatment protocols of high dose chemotherapy followed by autologous bone marrow transplantation. Double-Hit lymphoma is aggressive and can be fatal. Therefore, treatment should be initiated without delay after diagnosis.

Key Words: Double-Hit Lymphoma; Burkitt Like Lymphoma; Aggressive; Bone Marrow Transplantation.